International Research Center of Implantable and Interventional Medical Devices
Our center focused on multi-scale and cross-domain biomechanics and mechanobiology in human bone and cardiovascular systems based on theoretical innovation on implant and interventional medical instruments. Several dominate and distinctive studies, including design and evaluation of implant and interventional medical instruments, and research on patient-customized surgical planning. Combined with macro- and micro-investigation on organization and mechanical behaviors of biological tissue, we have developed experimental methods and technologies on modeling of quasi-physiological biomechanics and Mechanobiology. The methods and technologies would be used to study on the mechanical responses among stress, materials and typical cells (i.e. osteoclasts, stem cell, vascular endothelial cell, vascular smooth muscle cell, etc.), which also can be applied to evaluate the risk of postoperative complications.

For orthopedics implants, it was found that bio-mechanical response of implants and around bone tissue in the different stages of the bone fracture healings. Stress and strain distributions, total strain energy density (SED) along the femur and PFNA were analyzed in walking and stair climbing. The study on load-osseointegration animal experiments indicated that some pre-load from titanium implants benefits to the occurrence of osseointegration and improvement osseointegration quality. To predict the evolution of micro-architecture around implant systems using a computational bone remodeling model that combines both adaptive and microdamage-based mechano-sensory mechanisms. On the study of cardiovascular intervention, to investigate the interaction of the arteries, heart valves, stents, artificial blood vessels and blood flow in and around the surrounding vascular tissue, the relationship between load environment and arterial remodeling based on the simulation of cardiovascular hemodynamics.